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Thursday, July 23, 2020 | History

2 edition of Selection of an internal standard for postmortem ethanol analysis found in the catalog.

Selection of an internal standard for postmortem ethanol analysis

Selection of an internal standard for postmortem ethanol analysis

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  • 27 Currently reading

Published by U.S. Dept. of Transportation, Federal Aviation Administration, Office of Aviation Medicine, Available to the public through the National Technical Information Service in Washington, D.C, Springfield, Va .
Written in English

    Subjects:
  • Aircraft accidents -- Investigation.,
  • Alcohol in the body -- Testing.,
  • Air pilots -- Alcohol use.,
  • Autopsy.

  • Edition Notes

    StatementDennis V. Canfield ... [et al.].
    SeriesDOT/FAA/AM -- 98/5., DOT/FAA-AM -- 98/5.
    ContributionsCanfield, Dennis V., United States. Office of Aviation Medicine., Civil Aeromedical Institute.
    The Physical Object
    FormatMicroform
    Paginationi, 7 p.
    ID Numbers
    Open LibraryOL15505367M

    serial alcohol standard solutions was purchased from Labort GMBH Berlin (West). The internal standard (IS), t-butanol, used in the headspace gas chromatography (HSGC) was ordered from Panreac Quimica, SA, USA. Johnnie walker whisky containing 43 % of ethanol was bought at a supermarket in Taipei. Sample collection and preparation. Blood alcohol (ethanol) concentrations in decomposed bodies can mean drinking during life and/or endogenous production after death. The correct interpretation is important in medicolegal cases. This retrospective study of autopsied medical examiner cases was undertaken to evaluate alcohol concentrations and distribution in various fluids Cited by:

    Zoroastrow OM, Avramenko EP () Selection of materials, as substitutes for blood for the quantitative determination of ethanol in post-mortem forensic medical studies. Sovrem Vopr Sud Med Ekspertnoi Prakt Google ScholarCited by: 4. Ethanol was determined by gas chromatography in a variety of tissues and body fluids secured at autopsy in 61 cases. The specimens tested included right and left heart blood, femoral blood, pericardial fluid, cerebrospinal fluid, vitreous humor, urine, stomach contents, and by:

    analysis of EtG (8), by extending the analysis time and moni- toring the pseudomolecular ion for EtS. The method allowed for the simultaneous determination of EtS and EtG (17). Urine was mixed (v/v) with the internal standard (EtG-d5 in dis- tilled water; in future work, EtS-d5 at m/z t30 is also used) andFile Size: KB. Certificate of Analysis. Standard Reference Material Ethanol-Water Solution (Nominal Mass Fraction %) This Standard Reference Material (SRM) is a solution of ethanol (ethyl alcohol: Chemical Abstracts Service[CAS] Registry Number ) in water at a nominal concentration of % by mass. SRM is intended primarily.


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Selection of an internal standard for postmortem ethanol analysis Download PDF EPUB FB2

Get this from a library. Selection of an internal standard for postmortem ethanol analysis. [Dennis V Canfield; United States. Office of Aviation Medicine.; Civil Aeromedical Institute.;]. Title: Selection of an Internal Standard for Postmortem Ethanol Analysis Author: Canfield, D.V., Smith, M.D., Adams, H.J., and Houston, E.R.

Keywords. ethanol analysis in postmortem specimens. The following criteria were emphasized in selecting an improved internal standard: (1) The chemical prop-erties of the internal standard must be similar to the chemical properties of the compounds being quan-titated or separated; (2) The retention time of the internal standard should be in the middle.

interpreting ethanol results in postmortem specimens. The microbial formation of ethanol in postmortem specimens is the most significant problem encountered when evaluating ethanol results. The first report dealing with postmortem ethanol production in corpses ap-peared in (1).

At that time, a postmortem increase in ethanol concentration. Ethanol analysis is the most frequently performed assay in forensic toxicology laboratories. Interpretation of postmortem ethanol findings are often confounded by.

The significance of the microbial produced volatiles on the selection of an appropriate internal standard for the ethanol analysis has been considered.

Finally, the possible contribution of the presence of volatiles in the interpretation of ethanol analysis results in post-mortem cases is Cited by: Use an external standard calibration to get a working calibration for your system, and then use the internal standard to account for run-to-run variability.

Cite 1 Recommendation. Review Interpreting results of ethanol analysis in postmortem specimens: A review of the literature Fredrik C.

Kugelberga, Alan Wayne Jonesb,c,* a Department of Forensic Medicine, Karolinska Institutet, SE 77 Stockholm, Sweden bDepartment of Forensic Genetics and Forensic Chemistry, National Board of Forensic Medicine, SE 33 Linko¨ping, Sweden c University Cited by: internal standard 2-Butanol was also separated on both columns with a run time under five minutes.

Labs would have the option to use either internal standard, for routine testing and maintain fast analysis times. A further benefit of the Zebron™ column pair was the increased resolution and high reproducibility of ethanol from other close.

Interpreting postmortem ethanol concentration is simplified thanks to a much larger selection of body fluids and tissues available for sampling and analysis of alcohol.

The traditional and recommended body fluids for analysis of alcohol and other drugs are femoral blood, bladder urine and VH (Table 2).Cited by: Importance Of Sampling Sites For Postmortem Evaluation Of Ethanol.

Author(s): Can O I, Ozkara E, Salacin S, Gumustekin M. Abstract. Detection of ethyl alcohol and its origin in postmortem specimens is essential in terms of medico-legal aspects. It is a complicated process to determine whether alcohol has been taken in the ante-mortem. Because of the discrepancy in the ethanol results for the hospital blood and urine, the urine analysis was repeated, resulting in g% ethanol in urine.

As the production of ethanol seemed to be increasing with each analysis, the urine specimen was reanalyzed multiple times over a three-month period. Analysis of cocaine, its metabolites, pyrolysis products, and ethanol adducts in postmortem fluids and tissues using Zymark automated solid-phase extraction and gas chromatography-mass spectrometry.

Cocaine (COC) is one of the most widely abused illicit drugs in America. COC abuse transcends all social, racial, and economic boundaries. Preparation of the blood samples for analysis was carried out by measuring mL of blood in the glass container vial (volume 20 mL), and then by adding g NaCl and mL % solution of n-propanol (propyl alcohol pro analysi, Merck KGaA, Germany) as the internal standard.

Ethanol analysis was performed by the gas-chromatography method Cited by: chemistry and metabolism of ethanol, the process of putrefaction and the production of alcohol by micro-organisms after death will be provided. Laboratory methods of ethanol analysis and the range of specimens used will be described.

Difficulties associated with assessment of post-mortem blood alcohol levels will be discussedFile Size: KB. Ethanol analysis is the most frequently performed assay in forensic toxicology laboratories.

Interpretation of postmortem ethanol findings are often confounded by postmortem production of species of bacteria, yeast, and molds are capable of producing ethanol from a variety of substrates.

The probability of postmortem ethanol synthesis increases as storage. Kugelberg FC(1), Jones AW. Author information: (1)Department of Forensic Medicine, Karolinska Institutet, SE 77 Stockholm, Sweden. We searched the scientific literature for articles dealing with postmortem aspects of ethanol and problems associated with making a correct interpretation of the Cited by: Importance of Sampling Sites for Postmortem Evaluation of Cited by: 2.

Ethanol analysis is the most frequently performed assay in forensic toxicology laboratories. Interpretation of postmortem ethanol findings are often confounded by postmortem production of ethanol. Many species of bacteria, yeast, and molds are capable of producing ethanol from a variety of by: analysis can give a good idea about the presence and levels of alcohol in different post-mortem samples.

Drug and blood chemical level data for more than drugs including alcohol is published [1]. This data is used to differentiate between the therapeutic, toxic and lethal drug concentrations mainly in the : S.

Menshawi, L. Al-Alousi. Formic acid (formate) is the main reason for toxicity and death through methanol poisoning.

The simultaneous determination of methanol, ethanol, and formate in the body can help to discover the cause of death and is useful in the diagnosis of acute methanol poisoning.

The measurement of formate is not yet available in Iran. With regard to the increasing rate of Cited by: 5.Related Articles Interpreting results of ethanol analysis in postmortem specimens: a review of the literature. Forensic Sci Int. Jan 5;(1) Authors: Kugelberg FC, Jones AW Abstract We searched the scientific literature for articles dealing with postmortem aspects of ethanol and problems associated with making a correct interpretation of the results.

A person's blood .During toxicological evaluations, ethanol analysis is performed on all cases. Many species of bacteria, yeast and fungi have the ability to produce ethanol and other volatile organic compounds in postmortem specimens. The potential for postmortem ethanol formation complicates the interpretation of ethanol positive results from accident victims.